The Most Alarming Problem about Long COVID

Chronic Fatigue Syndrome

Jessica suffers from standard Chronic Fatigue Syndrome. She hadn’t put her feet on the floor in 8 years. Doing so knocked her out. This is the type of illness that Long COVID patients should be fearing the most.

Is Long COVID Like Chronic Fatigue Syndrome?

One of the main issues with Long COVID is that it’s a long-term illness, but COVID hasn’t been around for a long time, so we don’t know what happens in the long term. How can we know what COVID will be in a few years?

How Long Is Long COVID’s Chronic Fatigue Syndrome?

We don’t know yet, because little time has passed. But we can look at two data points:

  1. Analogies: how do people evolve from traditional CFS?
  2. What’s the trajectory of Long Haulers (those with Long COVID)?

1. Analogies with CFS

Many people suffer from CFS for decades.

2. Trajectory of COVID Long Haulers

One study from English healthcare workers shows these symptoms 6 months after infection.

How Does Long COVID Chronic Fatigue Syndrome Affect Your Lifestyle?

It can destroy it.

Who Gets Long COVID’s Chronic Fatigue Syndrome?

  • That’s what it looks like for all Long COVID symptoms
  • It’s also what it looks like for CFS.

Can Vaccines Prevent Chronic Fatigue Syndrome from COVID?

Yes! Finally some good news.

  1. The COVID-19 virus (or other equivalent viruses for other CFS) survives inside the body forever, pushing the immune system to chronic alert level.
  2. The immune system becomes dysregulated, and stops fighting another set of viruses, which now are more free to roam and affect the body, which the immune system then needs to fight in a chronic war.
  3. A dysregulated immune system attacks the body itself. In this case, it would be an auto-immune disease.

Can We Treat CFS in Long COVID?

The bad thing about CFS is that, as far as I can see, it can last forever and has no proven cure.


The big takeaway is that there’s a high likelihood that the worst part of Long COVID is Chronic Fatigue Syndrome. We can’t be 100% sure, but it looks like it, it smells like it, it tastes like it, and it sounds like it. Like traditional CFS, COVID CFS:

  • Has the same symptoms.
  • Also appears after a viral infection.
  • Also affects women more, especially in their fertile years.
  • Also seems to be caused by a combination of remaining virus and immune system gone awry.
  • Would be chronic.
  • Has no known cure.
  • Unregistered deaths
  • Post-Intensive Care Syndrome
  • Chronic loss of smell



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Tomas Pueyo

2 MSc in Engineering. Stanford MBA. Ex-Consultant. Creator of applications with >20M users. Currently leading a billion-dollar business @ Course Hero